Lusaka is a difficult, but not inaccessible location in 80 Days. Hotel, no market. The player may attempt to reach Lusaka from Nsenga to the north but will inevitably be surrounded and redirected to Ulundi courtesy of Emperor Cetshwayo.
Submersible named Questing Serpent will reach Lusaka from Dakar. 5 day trip, comfortable travel conditions, 4 luggage slots.
Stelle from the Black Rose Mystery must join and explore Dakar alongside Passepartout to unlock this route, which means this city is only accessible on even-numbered seeds when Stelle is available. This appears to be a game-ending condition only available if Passepartout chooses to abandon his service to Mr. Fogg in order to travel the world with Stelle at the end of the Black Rose Mystery, but confirmation needed.